CYTOKINES & IMMUNE TEST KIT 1 & 2 (scroll dwon for #2)


49 vials

Developed in collaboration with Dr Wally Schmitt, contains cytokines, including fibroblast growth factors, immunoglobulins, interleukins, etc.

NOTE: Do not buy the Interleukin Kit or the Immunoglobulin Kit if buying this kit, as the vials from these kits are included in this one.

CY 01 Amphiregulin/AREG
A member of the epidermal growth factor family. Interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines.

CY 02 Epidermal Growth Factor
Stimulates cell growth, proliferation, and differentiation. Can be found in platelets, macrophages, urine, saliva, human milk, and plasma.

CY 03 Fibroblast Growth Factor 1 /FGF-1
Growth factors involved in angiogenesis, wound healing, and embryonic development. Promotes endothelial cell proliferation and the physical organization of endothelial cells into tube-like structures. Stimulate angiogenesis and the proliferation of fibroblasts that give rise to granulation tissue, which fills up a wound space/cavity early in the wound-healing process. Seems to be involved in the regulation of synaptic plasticity and processes attributed to learning and memory, at least in the hippocampus.

CY 04 Fibroblast Growth Factor 2 / FGF-2
Growth factors involved in angiogenesis, wound healing, and embryonic development. Promotes endothelial cell proliferation and the physical organization of endothelial cells into tube-like structures. Stimulate angiogenesis and the proliferation of fibroblasts that give rise to granulation tissue, which fills up a wound space/cavity early in the wound-healing process. Adult neurogenesis within the hippocampus depends greatly on FGF-2. Seems to be involved in the regulation of synaptic plasticity and processes attributed to learning and memory, at least in the hippocampus.

CY 05 Fibroblast Growth Factor 10 / FGF-10
Growth factors involved in angiogenesis, wound healing, and embryonic development.

CY 06 Fibroblast Growth Factor 23 / FGF-23
Main function seems to be regulation of phosphate concentration in plasma. Secreted by osteoblasts and osteoclasts in response to elevated calcitriol. Acts on kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule, so decreases the reabsorption and increases excretion of phosphate.

CY 07 Granulocyte Colony-Stimulating Factor / G-CSF
A glycoprotein, growth factor and cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells, and then stimulates the bone marrow to release them into the blood. Also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.

CY 08 Granulocyte Macrophage Colony-Stimulating Factor/ GM-CSF
A protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. Functions as a white blood cell growth factor. Stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes.

CY 09 IgA
Found in mucosal areas, such as the gut, respiratory tract and urogenital tract, and prevents colonization by pathogens. Also found in saliva, tears, and breast milk.

CY 10 IgD
Functions mainly as an antigen receptor on B cells that have not been exposed to antigens. Has been shown to activate basophils and mast cells to produce antimicrobial factors.

CY 11 IgE
Binds to allergens and triggers histamine release from mast cells and basophils, and is involved in allergy. Also protects against parasitic worms.

CY 12 IgG
Provides the majority of antibody-based immunity against invading pathogens.The only antibody capable of crossing the placenta to give passive immunity to the foetus.

CY 13 IgM
Eliminates pathogens in the early stages of B cell mediated (humoral) immunity before there is sufficient IgG.

CY 14 Interferon-Alpha
Produced by leukocytes. They are mainly involved in innate immune response against viral infection.

CY 15 Interferon-Gamma
Critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. An important activator of macrophages. Aberrant IFN- expression is associated with a number of auto-inflammatory and auto-immune diseases.

CY 16 Interleukin-1
Stimulates the growth and action of immune system cells that fight disease, by participating in the regulation of immune responses, inflammatory reactions, and hematopoiesis (development of mature blood cells). Also helps leukocytes pass through blood vessel walls to sites of infection and causes fever by affecting areas of the brain that control body temperature.

CY 17 Interleukin-2
Induces the proliferation of responsive T-cells, and acts on some B-cells, via receptor-specific binding, as a growth factor and antibody production stimulant. Linked to pruritus (itching).

CY 18 Interleukin-3
Regulates blood-cell production by controlling the production, differentiation and function of granulocytes and macrophages, so enhances the immune system’s ability to fight tumor cells.

CY 19 Interleukin-4
Enhances the immune system’s ability to fight tumor cells; has an important function in B-cell responses. A key regulator in humoral and adaptive immunity.

CY 20 Interleukin-5
Regulates eosinophil growth and activation, and thus plays an important role in diseases associated with increased levels of eosinophils, including asthma and allergic rhinitis.

CY 21 Interleukin-6
A biomarker for inflammation and chronic disease. Plays an essential role in the final differentiation of B-cells into IG-secreting cells, as well as inducing myeloma/plasmacytoma growth, nerve cell differentiation, and, in hepatocytes, acute-phase reactants. Involved in diabetes, atherosclerosis, depression Alzheimer’s disease, systemic lupus erythematosus, prostate cancer and rheumatoid arthritis.

CY 22 Interleukin-7
Enhances the immune system’s ability to fight tumor cells. IL-7 is made by cells in the bone marrow, and can stimulate T cells and B cells to grow. Promotes acute lymphoblastic leukemia, T cell lymphoma. Elevated levels of IL-7 have also been detected in the plasma of HIV-infected patients.

CY 23 Interleukin-8
Induces chemotaxis in target cells, primarily neutrophils but also other granulocytes, causing them to migrate toward the site of infection. Also induces phagocytosis once they have arrived. Known to be a potent promoter of angiogenesis (growth of new blood vessels from existing ones, and necessary for tumours to grow). Often associated with inflammation (e.g. in gingivitis and psoriasis). If a pregnant mother has high levels, there is an increased risk of schizophrenia in her offspring. High levels have also been shown to reduce the likelihood of positive responses to antipsychotic medication in schizophrenia.

CY 24 Interleukin-9
Serves as a growth factor for early lymphoid cells of both B- and T-cell lineages. supports IL-2 independent and IL-4 independent growth of helper T-cells.

CY 25 Interleukin-10
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF, and GM-CSF produced by activated macrophages and by helper T cells. Mice studies suggest it is an essential immuno-regulator in the intestinal tract; may be relevant in Crohn’s disease.

CY 26 Interleukin-11
Stimulates megakaryocytopoiesis, resulting in increased production of platelets, as well as activating osteoclasts, inhibiting epithelial cell proliferation and apoptosis, and inhibiting macrophage mediator production. May reduce toxicity to the gastrointestinal system resulting from cancer therapy.

CY 27 Interleukin-12
Enhances the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor. Involved in the stimulation and maintenance of Th1 cellular immune responses, including the normal host defence against various intracellular pathogens, such as Leishmania, Toxoplasma, measles virus, and HIV. Also has an important role in pathological Th1 responses, such as in inflammatory bowel disease and multiple sclerosis.
Administration of IL-12 to people suffering from autoimmune diseases was shown to worsen the autoimmune phenomena. This is believed to be due to its key role in induction of Th1 immune responses.

CY 28 Interleukin-17A
A cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation, similar to Interferon gamma. Has been shown to have a pro-inflammatory role in asthma.

CY 29 Interleukin-23
Potently enhances the expansion of T helper type 17 cells, so involved in many of the inflammatory autoimmune responses.

CY 30 Lipopolysaccharide / LPS
Found in the outer membrane of Gram-negative bacteria, act as endotoxins and elicit strong immune responses. Produced by gut bacteria, so source of many inflammatory reactions including autoimmunity.

CY 31 Neuregulin 1 / NRG1
Induce the growth and differentiation of epithelial, neuronal, glial, and other types of cells. Essential for the normal development of the nervous system and the heart. Thought to play a role in schizophrenia. Part of the EGF family of proteins.

CY 32 Neuregulin 2 / NRG2
Induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. Part of the EGF family of proteins.

CY 33 Neuregulin 3 / NRG3
Linked to a susceptibility to schizophrenia and Hirschsprung’s disease. Part of the EGF family of proteins.

CY 34 Neuregulin 4 / NRG4
Activates type-1 growth factor receptors to initiate cell-to-cell signaling through tyrosine phosphorylation. Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.

CY 35 Platelet-Derived Growth Factor / PDGF-R
Plays a significant role in blood vessel formation (angiogenesis), the growth of blood vessels from already-existing blood vessel tissue. Uncontrolled angiogenesis is a characteristic of cancer.

CY 36 Transforming Growth Factor-Alpha / TGF Alpha
Seems to play a role in mediation of cell-cell adhesion and in juxtacrine stimulation of adjacent cells. Expression of TGF-alpha is widespread in tumors and transformed cells. TGF-alpha is also expressed in normal tissues during embryogenesis and in adult tissues, including pituitary, brain, keratinocytes and macrophages.

CY 37 Transforming Growth Factor-Beta / TGF-Beta
A protein that controls proliferation, cellular differentiation, and other functions in most cells. A type of cytokine which plays a role in immunity, cancer, bronchial asthma, heart disease, diabetes, Marfan syndrome, Loeys–Dietz syndrome, Parkinson’s disease and AIDS. May also be involved in allergic reactions.

CY 38 Tumor Necrosis Factor-Alpha
Produced by macrophages, which engulf and destroy bacteria, viruses, and other foreign substances; role in regulating inflammatory and immune responses throughout the body and particularly in relation to some parasites. Implicated in arthritis, rheumatoid arthritis, AIDS, multiple sclerosis, cancer; may be involved in septicaemia, and the weight loss associated with parasitic infection or cancer.

CY 39 Combined IL2 plus TGF-Beta
Screening for T Regulatory cell issues; helps direct T Regulatory synthesis.

CY 40 Combined IL23 plus TGF-Beta



13 vials

These are additional cytokines and immune regulating substances based on newer findings related to immune assessment.

1. The cost of this kit reflects the difficulty of obtaining high-quality starter material.
2. As with Kit ONE, this kit has been eveloped in collaboration with Dr Wally Schmitt

CY 41 Interleukin-1 Alpha / Hematopoietin 1
Produced mainly by activated macrophages, as well as neutrophInterleukins, epithelial cells, and endothelial cells; possesses metabolic, physiological, haematopoietic activities, and plays one of the central roles in the regulation of the immune responses; on the pathway that activates tumour necrosis factor-alpha.

CY 42 Interleukin-1 Beta / Leukocytic Pyrogen/ Leukocytic Endogenous Mediator/ Mononuclear Cell Factor/ Lymphocyte Activating Factor
Key mediator of the inflammatory response; essential for the host-response and resistance to pathogen; also exacerbates damage during chronic disease and acute tissue injury.

CY 43 Interleukin-17F
May be implicated in asthma and autoimmune diseases including rheumatoid arthritis, multiple sclerosis and inflammatory bowel diseases.

CY 44 Interleukin-18 / Interferon-Gamma Inducing Factor
Produced by macrophages and other cells; important role in the innate immune response; able to induce severe inflammatory reactions, which suggests its role in certain inflammatory disorders including adenomyosis and Hashimoto’s thyroiditis; has also been found to increase the Alzheimer’s disease-associated amyloid-beta production in human neuron cells; also a role in age-related macular degeneration.

CY 45 Interleukin-21
Has potent regulatory effects on cells of the immune system, including natural kInterleukinler cells and cytotoxic T cells that can destroy virally infected or cancerous cells; may have a role in controlling hyper-sensitive allergic responses.

CY 46 Interleukin-22
Initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells; probably plays a role in the coordinated response of both adaptive innate immune systems, auto-immunity and tissue regeneration; can contribute to immune disease through the stimulation of inflammatory responses.

CY 47 Interleukin-24 / Melanoma Differentiation-Associated 7
Mainly released by activated monocytes, macrophages and T helper 2; performs important roles in wound healing, arthritis, psoriasis and cancer.

CY 48 Interleukin-25 (also known as Interleukin-17E)
Induces the production of other cytokines, including Interleukin-4, Interleukin-5 and Interleukin-13 in multiple tissues, which stimulate the expansion of eosinophInterleukins; helps to control immunity of the gut; has been implicated in chronic inflammation of the gastrointestinal tract; potent anti-tumour activity including in melanoma, breast, lung, colon, and pancreatic cancers.

CY 49 TSLP (Thymic Stromal Lymphopoietin)
Produced mainly by non-hematopoietic cells such as fibroblasts, epithelial cells and different types of stromal or stromal-like cells in regions where TSLP activity is required; plays an important role in the maturation of T cell populations through activation of antigen presenting cells; linked to many disease states including asthma, inflammatory arthritis, atopic dermatitis, eczema, eosinophInterleukinic esophagitis and other allergic states.

CY 50 NFkB p50
Implicated in cell proliferation and differentiation, inflammatory and immune response, cell survival and apoptosis, cellular stress reactions and the development of tumours.

CY 51 NFkB p65 / RelA
Plays a crucial role in inflammatory and immune responses.

CY 52 HIF-1 N-terminal activation domain (530-698)
Considered as the master transcriptional regulator of cellular and developmental response to hypoxia (oxygen deficiency in cells); stimulates tumour growth and metastases.

CY 53 STAT5 / Signal Transducer And Activator Of Transcription 5, His tagged
Plays a major role in TH2 expression and Regulatory T cell expression; involved in cytosolic signalling and in mediating the expression of specific genes; closely connected to a wide range of human cancers.

Screening for Autoimmune issues.